Bone induction by composites of bioresorbable carriers and demineralized bone in rats: A comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin
| Autor: | Else Marie Pinholt, Gisle Bang, Eirik Solheim, Einar Sudmann |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Polyesters Bone Matrix Fibrin Tissue Adhesive Biocompatible Materials Absorption (skin) Giant Cells Fibrin Absorption Osteogenesis Animals Medicine Rats Wistar Composite material Skin Drug Carriers biology business.industry Macrophages Sealant Biomaterial Prostheses and Implants Rats Otorhinolaryngology Delayed-Action Preparations biology.protein Surgery Gentamicin Collagen Implant Gentamicins Oral Surgery Drug carrier business medicine.drug |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 50:1300-1304 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/0278-2391(92)90231-n |
| Popis: | Host tissue response and heterotopic osteoinduction by composites of demine4alized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealent inhibited bone induction and produced a chronic inflamation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction. |
| Databáze: | OpenAIRE |
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