Inhibition of δ-aminolevulinic acid synthetase by thioacetamide and thioacetamide-S-oxide
| Autor: | Robert A. Neal, Takemi Yoshida |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Pharmacology Mice Inbred ICR Time Factors Hydrocortisone Adult male Oxide δ-aminolevulinic acid Dicarbethoxydihydrocollidine Thioacetamide Biochemistry ALA synthetase Mice chemistry.chemical_compound chemistry Thioacetamide-S-oxide In vivo Enzyme Induction Acetamides Animals 5-Aminolevulinate Synthetase Tyrosine Transaminase |
| Zdroj: | Biochemical Pharmacology. 27:2095-2098 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(78)90278-2 |
| Popis: | Thiocetamide and one of its metabolites, thioacetamide- S -oxide, were shown to inhibit δ-aminolevulinic acid (ALA) synthetase when administered in vivo to adult male mice. Thioacetamide and thioacetamide- S -oxide also inhibited the 3,5-dicarboethoxy-1,4-dihydrocollidine (DDC)-mediated induction of ALA synthetase when given either 1hr prior to or 3 hr after the administration of DDC. The results of these studies also indicate that thioacetamide- S -oxide is generally a more potent inhibitor of ALA synthetase than thioacetamide. |
| Databáze: | OpenAIRE |
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