Targeted memory reactivation in REM but not SWS selectively reduces arousal responses
| Autor: | Mahmoud E. A. Abdellahi, Maria-Efstratia Tsimpanouli, Penelope A. Lewis, Stefania Pezzoli, Isabel C Hutchison, Gorana Pobric, Johann Hulleman |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
QH301-705.5 Emotions Medicine (miscellaneous) General Biochemistry Genetics and Molecular Biology Article Arousal Learning and memory Young Adult 03 medical and health sciences 0302 clinical medicine Memory Clinical Research Behavioral and Social Science Emotional memory Human behaviour Humans Habituation Biology (General) 030304 developmental biology Emotion 0303 health sciences Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Neurosciences Cognitive neuroscience Sleep in non-human animals Mental Health REM Slow-Wave Mental Recall Female Circadian rhythms and sleep Sleep Sleep Research General Agricultural and Biological Sciences Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes |
| Zdroj: | Communications biology, vol 4, iss 1 Hutchison, I C, Pezzoli, S, Tsimpanouli, M-E, Abdellahi, M E A, Pobric, G, Hulleman, J & Lewis, P A 2021, ' Targeted memory reactivation in REM but not SWS selectively reduces arousal responses ', Communications Biology, vol. 4, no. 1, 404 . https://doi.org/10.1038/s42003-021-01854-3 Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021) |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-021-01854-3 |
| Popis: | A growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation. Hutchison et al. played sounds, which were paired with either emotionally negative or neutral images, to participants during either REM or slow-wave stages of sleep. They demonstrated that such targeted memory reactivation during REM sleep, but not slow-wave sleep, significantly decreased arousal. This provides key information about memory consolidation/loss during sleep. |
| Databáze: | OpenAIRE |
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