Multi-omics Investigation into the Mechanism of Action of an Anti-tubercular Fatty Acid Analogue

Autor:	Isin T. Sakallioglu, Amith S. Maroli, Aline De Lima Leite, Darrell D. Marshall, Boone W. Evans, Denise K. Zinniel, Patrick H. Dussault, Raúl G. Barletta, Robert Powers
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry Mycolic Acids Bacterial Proteins Mycobacterium smegmatis Fatty Acids Antitubercular Agents Mycobacterium tuberculosis General Chemistry Biochemistry Catalysis
Zdroj:	Journal of the American Chemical Society. 144:21157-21173
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.2c08238
Popis:	The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were combined with a network analysis to investigate the MoA of DA-CB against
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be65424554290456a48dd286be35c7a https://doi.org/10.1021/jacs.2c08238 Zobrazit plný text záznamu