Analysis of PGT‐M and PGT‐SR outcomes at a Canadian fertility clinic
| Autor: | Gary S. Nakhuda, B. Taylor, Niamh Tallon, Rachel Butler, A. Albert Yuzpe, Chen Jing, Jason Hitkari, Nora Lee, Colleen Guimond |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Canada medicine.medical_specialty Pregnancy Rate Biopsy medicine.medical_treatment media_common.quotation_subject Inheritance Patterns Fertility Fertilization in Vitro Pregnancy medicine Humans Genetic Testing Preimplantation Diagnosis Genetics (clinical) Retrospective Studies Genetic testing media_common Chromosome Aberrations Fertility Clinics In vitro fertilisation medicine.diagnostic_test business.industry Obstetrics Genetic Diseases Inborn Pregnancy Outcome Obstetrics and Gynecology Embryo Retrospective cohort study Embryo Transfer Prognosis medicine.disease Fertility clinic Pregnancy rate Blastocyst embryonic structures Female business |
| Zdroj: | Prenatal Diagnosis. 39:866-870 |
| ISSN: | 1097-0223 0197-3851 |
| DOI: | 10.1002/pd.5496 |
| Popis: | Objective Outcomes from in vitro fertilization (IVF)/intrauterine insemination (ICSI) cycles for patients who underwent preimplantation genetic testing for monogenic/single gene (PGT-M) and structural chromosome rearrangements (PGT-SR) patients were reviewed. Patients pursuing PGT-M and PGT-SR often do not have pre-existing fertility issues and therefore may have uncertain expectations of successful outcomes. Before pursuing PGT-M and PGT-SR, patients require evidence-based counseling regarding the probability of having a healthy child. Method Retrospective review from a single private IVF clinic of 73 PGT patients, from whom a total of 437 blastocysts were biopsied and screened. Embryo results and pregnancy outcomes were analyzed. Results Of the 45 PGT-M patients, 64.4% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 89.7%, with an ongoing pregnancy or delivery rate of 48.9%. For the 28 PGT-SR patients, 60.7% had at least one euploid unaffected embryo. The cumulative pregnancy rate for patients who had embryo transfers in this group was 87.5%, with an ongoing pregnancy or delivery rate of 42.9%. Conclusion This information can supplement the existing data in the literature to counsel new patients in terms of realistic expectations of success following PGT-M and PGT-SR. |
| Databáze: | OpenAIRE |
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