Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

Autor: Bianca Weinstock-Guttman, Paul Polak, Michael G. Dwyer, Jürgen R. Reichenbach, Joshua Zalis, Robert Zivadinov, Niels Bergsland, Ferdinand Schweser, Jesper Hagemeier, Andreas Deistung
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
Pathology
medicine.medical_specialty
Multiple Sclerosis
Cognitive Neuroscience
Iron
Thalamus
Medizin
lcsh:Computer applications to medicine. Medical informatics
lcsh:RC346-429
030218 nuclear medicine & medical imaging
03 medical and health sciences
Myelin
0302 clinical medicine
Image Interpretation
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
Prospective Studies
Gray Matter
Prospective cohort study
Pathological
lcsh:Neurology. Diseases of the nervous system
Aged
Brain Mapping
Multiple sclerosis
QSM
Brain
Quantitative susceptibility mapping
Regular Article
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Globus pallidus
medicine.anatomical_structure
Cross-Sectional Studies
Neurology
lcsh:R858-859.7
Female
Neurology (clinical)
Analysis of variance
Longitudinal study
Psychology
030217 neurology & neurosurgery
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 18, Iss, Pp 1007-1016 (2018)
ISSN: 2213-1582
Popis: In multiple sclerosis, pathological changes of both tissue iron and myelin occur, yet these factors have not been characterized in a longitudinal fashion using the novel iron- and myelin-sensitive quantitative susceptibility mapping (QSM) MRI technique. We investigated disease-relevant tissue changes associated with myelin loss and iron accumulation in multiple sclerosis deep gray matter (DGM) over two years. One-hundred twenty (120) multiple sclerosis patients and 40 age- and sex-matched healthy controls were included in this prospective study. Written informed consent and local IRB approval were obtained from all participants. Clinical testing and QSM were performed both at baseline and at follow-up. Brain magnetic susceptibility was measured in major DGM structures. Temporal (baseline vs. follow-up) and cross-sectional (multiple sclerosis vs. controls) differences were studied using mixed factorial ANOVA analysis and appropriate t-tests. At either time-point, multiple sclerosis patients had significantly higher susceptibility in the caudate and globus pallidus and lower susceptibility in the thalamus. Over two years, susceptibility increased significantly in the caudate of both controls and multiple sclerosis patients. Inverse thalamic findings among MS patients suggest a multi-phase pathology explained by simultaneous myelin loss and/or iron accumulation followed by iron depletion and/or calcium deposition at later stages.
Highlights • QSM was used to investigate longitudinal tissue changes in MS and healthy brain. • Iron, myelin and calcium changes may be present in deep gray matter in MS. • Susceptibility was higher cross-sectionally in MS. • Thalamic findings suggest changes in iron, myelin and potentially calcium.
Databáze: OpenAIRE
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