The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis
| Autor: | Daniel Aeberli, Axel Finckh, Peter M. Villiger, Martin Fiedler, Almut Scherer, Burkhard Möller, Godehard Scholz, Uta Arndt, Cem Gabay, Diego Kyburz, Alexander Benedikt Leichtle |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Necrosis Hepcidin Inflammation Arthritis Rheumatoid Hemoglobins 03 medical and health sciences 0302 clinical medicine Hepcidins hemic and lymphatic diseases medicine Humans Anaemia of inflammation Rheumatoid arthritis 610 Medicine & health Erythropoietin ddc:616 Anemia Iron-Deficiency biology business.industry Hematology Iron deficiency Middle Aged Iron metabolism medicine.disease Haematopoiesis Cross-Sectional Studies 030220 oncology & carcinogenesis Immunology Interleukin-6 receptor Disease Progression biology.protein Female Joints medicine.symptom business 030215 immunology medicine.drug |
| Zdroj: | British Journal of Haematology, Vol. 186, No 1 (2019) pp. 101-112 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.15895 |
| Popis: | Anaemia affects quality of life and radiographic outcome in rheumatoid arthritis (RA). In a cross-sectional study with 779 patients, we assessed the prognostic potential of the major haematopoietic regulators, hepcidin and erythropoietin, comparing their serum concentrations with respect to different anaemia types, inflammatory activity, anti-cytokine-specific treatment effects and iron deficiency (ID) indices. The results showed that clinical disease activity was more closely associated with haemoglobin levels than with anti-tumour necrosis factor-alpha or interleukin 6 receptor effects. In ID, hepcidin was suppressed, independently of inflammation. Erythropoietin levels were inappropriately low in relation to the degree of anaemia, but, in contrast to low haemoglobin, not directly associated with joint damage progression. Hepcidin and erythropoietin levels are intimately connected with inflammation and ID. Interventional studies on these important targets are already in progress. |
| Databáze: | OpenAIRE |
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