Surrogate Markers of Subclinical Atherosclerosis and Its Associated Factors in Patients with β-Thalassemia Major
| Autor: | Danesh Soltani, Farshad Sharifi, Hossein Fakhrzadeh, Mohammad Jafar Mahmoudi, Elham Mahmoudi, Ali Vasheghani-Farahani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Insulins Iran Carotid Intima-Media Thickness Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Humans Medicine In patient Genetics (clinical) business.industry beta-Thalassemia Biochemistry (medical) Hematology Atherosclerosis 030220 oncology & carcinogenesis Subclinical atherosclerosis Hemoglobin business β thalassemia major Biomarkers 030215 immunology |
| Zdroj: | Hemoglobin. :1-5 |
| ISSN: | 1532-432X 0363-0269 |
| DOI: | 10.1080/03630269.2021.1907405 |
| Popis: | β-Thalassemia major (β-TM) is a severe genetic hemoglobin (Hb) disorder with cardiovascular complications such as atherosclerosis due to transfusion-dependent iron overload. We aimed to determine the associated factors with surrogate markers of subclinical atherosclerosis in these patients. Sixty subjects with β-TM referred to the Thalassemia Clinic of the Iranian Blood Transfusion Organization (IBTO) were included in our study. The blood samples were collected for laboratory measurements. The carotid intima-media thickness (CIMT), was measured by ultrasonography, and ankle-brachial index (ABI) was calculated. The multivariate linear analysis was performed to determine the appropriate indicators of subclinical atherosclerosis in β-TM. There was no significant difference in baseline characteristics between the study groups. In multivariate linear analysis, age and systolic blood pressure (SBP) were negatively associated with inverse-transformed CIMT [unstandardized β coefficient (B): -0.024, 95% confidence interval (95% CI): -0.032- -0.010 |
| Databáze: | OpenAIRE |
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