Intra-operative radiotherapy (IORT) in pancreatic cancer: joint analysis of the ISIORT-Europe experience
| Autor: | Gian Carlo Mattiucci, Valerio Di Carlo, Giuseppe D'Agostino, Michele Reni, Markus W. Büchler, Alessio G. Morganti, J.L. Garcia-Sabrido, Felix Sedlmayer, Gerd Fastner, Falk Roeder, Giovanni Battista Doglietto, Vincenzo Valentini, Robert Krempien, Felipe A. Calvo, Paolo Passoni |
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| Přispěvatelé: | Valentini, V, Calvo, F, Reni, M, Krempien, R, Sedlmayer, F, Buchler, Mw, Di Carlo, V, Doglietto, Gb, Fastner, G, Garcia-Sabrido, Jl, Mattiucci, G, Morganti, Ag, Passoni, P, Roeder, F, D'Agostino, Gr, Valentini, Vincenzo, Calvo, Felipe, Reni, Michele, Krempien, Robert, Sedlmayer, Felix, Buchler, Markus W., Carlo, Valerio Di, Doglietto, Giovanni B., Fastner, Gerd, Garcia-Sabrido, José L., Mattiucci, Giancarlo, Morganti, Alessio G., Passoni, Paolo, Roeder, Falk, D'Agostino, Giuseppe R |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment IORT Adenocarcinoma Follow-Up Studie Intraoperative Period Pancreatic cancer medicine Carcinoma Combined Modality Therapy Humans Radiology Nuclear Medicine and imaging Adverse effect Survival rate Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA Proportional Hazards Models Proportional hazards model business.industry Pancreatic Neoplasm Radiotherapy Dosage Hematology medicine.disease Surgery Radiation therapy Europe Pancreatic Neoplasms Survival Rate Treatment Outcome Oncology Proportional Hazards Model Female Joint analysi business Human Follow-Up Studies |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 91(1) |
| ISSN: | 0167-8140 |
| Popis: | Purpose: A joint analysis of data from five contributing centers within the ISIORT-Europe program was performed to investigate the main contributions of intra-operative radiotherapy (IORT) to the multidisciplinary treatment of pancreatic cancer. Materials and methods: Patients with a histologic diagnosis of carcinoma of the pancreas, with an absence of distant metastases, undergoing surgery with radical intent and IORT were considered eligible for participation in this study. Results: From 1985 to 2006, a total of 270 patients were enrolled in the study from five European Institutions. Surgery was performed in 91.5% of cases and complicated by adverse events in 59 cases. External radiotherapy (ERT) preceded surgery in 23.9% of cases. One-hundred and six patients received further ERT. After surgery + IORT, median follow-up was 96 months (range 3-180). Median local control was 15 months, 5-year local control was 23.3%. Median overall survival was 19 months, while 5-year survival was 17.7%. A significantly greater local control and survival were observed in patients undergoing preoperative radiotherapy (LC: median not reached; OS: median 30 months) compared to patients treated with postoperative ERT alone (LC: median 28 months; OS: median 22 months), and to patients submitted to IORT exclusively (LC: median 8 months; OS: median 13 months) (p < 0.0001). Conclusion: From this joint analysis emerges the fact that preoperative radiotherapy increases the effects of IORT in terms of local control and overall survival. The 5-year local control of 23.3% confirms the beneficial "sterilizing" effect of IORT on the tumor bed. (C) 2008 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 54-59 |
| Databáze: | OpenAIRE |
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