Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex
| Autor: | Virginie Lafont, Serge Monier, Andrés Alcover, Jacques Dornand, Arnaud Dupuy D'Angeac, Jean Favero |
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| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cell signaling CD4 antigen CD3 Complex CD3 Receptors Antigen T-Cell alpha-beta Immunology Cell In Vitro Techniques chemistry.chemical_compound Antigen T-Lymphocyte Subsets Lectins medicine Immunology and Allergy Humans chemistry.chemical_classification biology Lectin Cell Biology Molecular biology Genistein Isoflavones Cell biology medicine.anatomical_structure chemistry CD4 Antigens biology.protein Jacalin Calcium Plant Lectins Glycoprotein |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0741-5400 |
| Popis: | The lectin jacalin interacts with the CD4 cell surface antigen; this lectin inhibits in vitro infection by human immunodeficiency virus type 1 without preventing virus binding on the host cell. The infection process is known to involve cellular events triggered by the binding of the viral external glycoprotein gp120 to CD4. Herein we demonstrate that jacalin induces cell signaling directly through the CD4 antigen and that independently of the CD3/TcR complex. The capacity of jacalin to trigger cell signals through the CD4 molecule is discussed in relation to its ability to inhibit HIV infection. J. Leukoc. Biol. 56: 521–524; 1994. |
| Databáze: | OpenAIRE |
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