Clinical efficacy and tolerability of Gabapentinoids with current prescription patterns in patients with Neuropathic pain
| Autor: | Moosa Khan, Abida Shaheen, Arsalan Ahmad, Syed Mahboob Alam |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Gabapentin Population Pregabalin Gabapentinoids Neuropathic pain 03 medical and health sciences 0302 clinical medicine Internal medicine Current dosages medicine 030212 general & internal medicine education Adverse effect education.field_of_study Adverse effects business.industry General Medicine medicine.disease Discontinuation Tolerability Pain relief Radicular pain Original Article business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X 1682-024X |
| DOI: | 10.12669/pjms.35.6.652 |
| Popis: | Objective: To investigate the current dosing regimens of gabapentinoids in Pakistani patients with neuropathic pain and to compare their clinical efficacy and tolerability in terms of pain relief and adverse effects using difference in pain score as a treatment outcome. Methods: This observational, prospective study was conducted in 320 patients with neuropathic pain from August 2016 to March 2018 at Basic Medical Sciences Institute (BMSI), Karachi in collaboration with Shifa International Hospital and Benazir Bhutto Hospital, Islamabad. Demographic data, treatment-related adverse effects and pain intensity was documented at recruitment and follow up visits at two, four and eight weeks. Discontinuation due to adverse effects and lack of efficacy were also recorded. Data was entered and analyzed using SPSS version 22. Results: Mean age of patients was 52.57±12.47 and the most common ethnicity were Punjabi speaking population (66%). Diabetic neuropathy (51%) was the most common etiology followed by radicular pain (25%). Mean dosages of pregabalin and gabapentin were 114mg and 470mg respectively. Mean pain score was significantly reduced by gabapentinoids ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|