Release of gonadotropins by oral administration of synthetic LRF or a tripeptide fragment of LRF
| Autor: | Jean Rivier, Roger Guillemin, Max Amoss |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Time Factors Chemistry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Radioimmunoassay Tripeptide Luteinizing Hormone Biochemistry Rats Endocrinology Oral administration Internal medicine medicine Animals Female Follicle Stimulating Hormone Peptides Pituitary Hormone-Releasing Hormones |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 35(1) |
| ISSN: | 0021-972X |
| Popis: | The oral administration to rats of synthetic LRF or of the (amidated) N-terminal tripeptide-fragment of LRF is capable of eliciting a statistically significant increase in plasma LH, the highest dose of LRF also elevating plasma FSH. The highest dose of LRF, as well as the two doses of the tripeptide, produced elevations of plasma LH sustained for at least 1 hr. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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