Behavioral and EEG changes in male 5xFAD mice
| Autor: | Wolfram Wetzel, F. Schneider, K. Baldauf, Klaus G. Reymann |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetically modified mouse
Male Elevated plus maze medicine.medical_specialty psychology [Alzheimer Disease] Rapid eye movement sleep physiopathology [Anxiety] Alpha (ethology) Morris water navigation task Experimental and Cognitive Psychology genetics [Alzheimer Disease] Mice Transgenic physiopathology [Brain] Anxiety physiopathology [Alzheimer Disease] Presenilin Open field Behavioral Neuroscience PSEN1 protein human Amyloid beta-Protein Precursor Mice physiology [Maze Learning] Alzheimer Disease Internal medicine ddc:570 medicine Amyloid precursor protein Presenilin-1 Animals genetics [Anxiety] Maze Learning biology Behavior Animal Brain Electroencephalography genetics [Presenilin-1] physiology [Sleep] physiology [Behavior Animal] Disease Models Animal Endocrinology genetics [Amyloid beta-Protein Precursor] psychology [Anxiety] biology.protein Exploratory Behavior Psychology Sleep Neuroscience physiology [Exploratory Behavior] |
| Zdroj: | Physiology & behavior 135, 25-33 (2014). doi:10.1016/j.physbeh.2014.05.041 |
| ISSN: | 1873-507X |
| DOI: | 10.1016/j.physbeh.2014.05.041 |
| Popis: | Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early development of parenchymal plaque load at the age of 2months is the 5xFAD mouse (Tg6799, Oakley et al. 2006). These 5xFAD mice over-express both human amyloid precursor protein (APP) and human presenilin 1 (PS1). Mice from this line have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β (Aβ). The aim of this study was the behavioral and functional investigations of 5xFAD males because in most studies females of this strain were characterized. In comparison to literature of transgenic 5xFAD females, transgenic 5xFAD males showed decreased anxiety in the elevated plus maze, reduced locomotion and exploration in the open field and disturbances in learning performance in the Morris water maze starting at 9months of age. Electroencephalogram (EEG) recordings on 6month old transgenic mice revealed a decrease of delta, theta, alpha, beta and gamma frequency bands whereas the subdelta frequency was increased. EEG recordings during sleep showed a reduction of rapid eye movement sleep in relation to the amount of total sleep. Thus, 5xFAD males develop early functional disturbances and subsequently behavioral deficits and therefore they are a good mouse model for studying Alzheimer's disease. |
| Databáze: | OpenAIRE |
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