Changes in Total Cholesterol and Heart Rate in Normotensive and Hypertensive Rats under Combined Influence of Cold Exposure and Hypokinesia
| Autor: | N. A. Kibler, S. N. Kharin, V. P. Nuzhny, Dmitry Shmakov |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Cold exposure Energy metabolism Blood Pressure Hypokinesia Rats Inbred WKY General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Heart Rate Internal medicine Total cholesterol Rats Inbred SHR Heart rate medicine Animals Rats Wistar Cholesterol business.industry Heart General Medicine Serum concentration Rats Cold Temperature 030104 developmental biology Endocrinology chemistry Hypertension Seasons medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 169(6) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effect of hypokinesia alone and in combination with cold exposure on HR and total cholesterol content in the blood serum of Wistar, WKY, and SHR rats. Irrespectively of the season, hypokinesia was associated with a decrease in HR, which is probably a result of reduced body needs due to deceleration of metabolic processes. A significant increase in total cholesterol was found under conditions of cold exposure combined with hypokinesia, which indicates qualitative structural rearrangement of energy metabolism under the influence of environmental factors. In winter, the increase in total cholesterol concentration was more pronounced (by 51.5%) in the group of hypertensive animals. Presumably, the increase in the serum concentration of total cholesterol under conditions of hypokinesia and cold exposure is a predictor of structural changes in the heart. |
| Databáze: | OpenAIRE |
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