Bedside breath tests in Children with abdominal pain: a Prospective Pilot Feasibility Study
| Autor: | Jonathan Sutcliffe, David Wong, Samuel D. Relton, Victoria Lane, Jim Deuchars, Robert West, Victoria Goss, Mohamed A Ismail, Jane Bytheway |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Abdominal pain
medicine.medical_specialty Referral Medicine (miscellaneous) Logistic regression 03 medical and health sciences 0302 clinical medicine Primary outcome Patient age 030225 pediatrics medicine Volatile organic compounds Child Breathomics lcsh:R5-920 Receiver operating characteristic business.industry Research Appendicitis medicine.disease 030228 respiratory system Exhalation Emergency medicine Suspected appendicitis medicine.symptom lcsh:Medicine (General) business Biomarkers |
| Zdroj: | Wong, D, Relton, S, Lane, V, Ismail, M, Goss, V, Bytheway, J, West, R, Deuchars, J & Sutcliffe, J 2019, ' Bedside breath tests in Children with abdominal pain: a Prospective Pilot Feasibility Study ', Pilot and Feasibility Studies, vol. 5, 121 . https://doi.org/10.1186/s40814-019-0502-x Pilot and Feasibility Studies, Vol 5, Iss 1, Pp 1-8 (2019) Pilot and Feasibility Studies |
| ISSN: | 2055-5784 |
| DOI: | 10.1186/s40814-019-0502-x |
| Popis: | Background There is no definitive method of accurately diagnosing appendicitis before surgery. We evaluated the feasibility of collecting breath samples in children with abdominal pain and gathered preliminary data on the accuracy of breath tests. Methods We conducted a prospective pilot study at a large tertiary referral paediatric hospital in the UK. We recruited 50 participants with suspected appendicitis, aged between 5 and 15 years. Five had primary diagnosis of appendicitis. The primary outcome was the number of breath samples collected. We also measured the number of samples processed within 2 h and had CO2 ≥ 3.5%. Usability was assessed by patient-reported pain pre- and post-sampling and user-reported sampling difficulty. Logistic regression analysis was used to predict appendicitis and evaluated using the area under the receiver operator characteristic curve (AUROC). Results Samples were collected from all participants. Of the 45 samples, 36 were processed within 2 h. Of the 49 samples, 19 had %CO2 ≥ 3.5%. No difference in patient-reported pain was observed (p = 0.24). Sampling difficulty was associated with patient age (p = 0.004). The logistic regression model had AUROC = 0.86. Conclusions Breath tests are feasible and acceptable to patients presenting with abdominal pain in clinical settings. We demonstrated adequate data collection with no evidence of harm to patients. The AUROC was better than a random classifier; more specific sensors are likely to improve diagnostic performance. Trial registration ClinicalTrials.gov, NCT03248102. Registered 14 Aug 2017. |
| Databáze: | OpenAIRE |
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