Cotreatment with growth hormone for induction of spermatogenesis in patients with hypogonadotropic hypogonadism
| Autor: | Najiba Lahlou, Howard S. Jacobs, Gerard S. Conway, Philippe Bouchard, Hanne Ostergaard, Zeev Shoham |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Menotropins medicine.drug_class Physiology Biology Growth hormone Chorionic Gonadotropin Human chorionic gonadotropin Gonadotropin-Releasing Hormone Human reproduction Hypogonadotropic hypogonadism Internal medicine Humans Endocrine system Medicine Testosterone In patient Spermatogenesis Sperm Count business.industry Hypogonadism Osmolar Concentration Obstetrics and Gynecology General Medicine medicine.disease Sperm Endocrinology Reproductive Medicine Growth Hormone Embryology Gonadotropin Luteinizing hormone business Gonadotropins Hormone |
| Zdroj: | Fertility and Sterility. 57:1044-1051 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)55023-7 |
| Popis: | Objective To induce spermatogenesis by cotreatment with growth hormone (GH) and gonadotropin therapy in patients with hypogonadotropic hypogonadism who had failed to respond adequately to conventional treatment. Design Cotreatment with GH (4 IU) and human menopausal gonadotropin, 150IU of follicle-stimulating hormone and 150IU of luteinizing hormone (LH), three times a week, and human chorionic gonadotropin, 2,500 IU, two times a week for 24 weeks after unsuccessful treatment for 12 weeks with either pulsatile LH-releasing hormone or gonadotropins. Setting Specialist Reproductive Endocrine Unit. Patients, Participants Seven patients, four of whom had failed to respond adequately to the conventional treatment. Main Outcome Measures Serum testosterone (T), estradiol, and sperm production, testicular and semen volume, and serum insulin-like growth factor-I and inhibin concentrations. Results Of the four patients who received cotreatment with GH, three increased T secretion (>11 nmol/L) within a relatively short period of time, two produced adequate amount of sperm (13 and 12 × 10 6 /mL), and one of them impregnated his wife. One patient did not respond. Conclusion The results offer a new approach to the problem of induction of spermatogenesis in patients who respond poorly to conventional treatment because cotreatment with GH enhanced T secretion and sperm production in a relatively short period of time. |
| Databáze: | OpenAIRE |
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