Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potentially Arrhythmogenic Scar in Patients with Acute Myocardial Infarction

Autor: Roger Borràs, Ada Doltra, David Soto-Iglesias, Xavier Bosch, Manuel Morales-Ruiz, Rosario J. Perea, Susana Prat-González, Aurea Mira, Antonio Berruezo, Neus Villamor, Luis Lasalvia, Beatriz Jáuregui, Wladimiro Jiménez, Diego Penela, José T. Ortiz-Pérez
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Time Factors
CD14
Lipopolysaccharide Receptors
Pharmaceutical Science
030204 cardiovascular system & hematology
CD16
GPI-Linked Proteins
Arrhythmogenic substrate
Monocytes
Ventricular Function
Left
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Risk Factors
Internal medicine
Genetics
medicine
Humans
In patient
Prospective Studies
cardiovascular diseases
Myocardial infarction
Genetics (clinical)
Aged
Ejection fraction
Ventricular Remodeling
Ventricular function
business.industry
Myocardium
Receptors
IgG
Arrhythmias
Cardiac
Stroke Volume
Middle Aged
medicine.disease
Infarct size
Magnetic Resonance Imaging
Treatment Outcome
030104 developmental biology
cardiovascular system
Cardiology
ST Elevation Myocardial Infarction
Molecular Medicine
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Journal of Cardiovascular Translational Research. 13:722-730
ISSN: 1937-5395
1937-5387
DOI: 10.1007/s12265-019-09944-8
Popis: To investigate the role of classical (CLM, CD14++CD16−), intermediate (INTM, CD14++CD16+), and non-classical (Non-CLM, CD14+CD16++) monocytes in scar formation after ST-elevation myocardial infarction (STEMI), evaluated with cardiac magnetic resonance (CMR). One hundred two patients with a first STEMI had serial blood analyses after 1, 3, and 7 days. A CMR was performed at 7 days and 6 months, depicting scar core (CO), border zone (BZ), and the presence of BZ channels. CLM and INTM levels progressively decreased, correlated with the scar mass, CO, and BZ at 7 days and 6 months (p
Databáze: OpenAIRE
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