Efficacy of inactivated whole HIV-2 vaccines with various adjuvants in cynomolgus monkeys
| Autor: | Lili Ghavamzadeh, Per Putkonen, Kerstin Hild, Charlotta Nilsson, Gunnel Biberfeld, Kristina Broliden, Lilian Walther, Rigmor Thorstensson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_treatment HIV Antibodies Virus Replication Genes env Polymerase Chain Reaction Cell Line chemistry.chemical_compound Adjuvants Immunologic Animals Medicine Lymphocytes HIV Long Terminal Repeat AIDS Vaccines Antibody-dependent cell-mediated cytotoxicity Acquired Immunodeficiency Syndrome General Veterinary biology business.industry Alum Antibody-Dependent Cell Cytotoxicity Genes gag Genes pol Virology Macaca fascicularis Titer Vaccines Inactivated chemistry Immunization Viral replication HIV-2 Inactivated vaccine Immunology biology.protein Female Animal Science and Zoology Lymph Nodes Antibody business Adjuvant |
| Zdroj: | Journal of Medical Primatology. 23:89-94 |
| ISSN: | 0047-2565 |
| DOI: | 10.1111/j.1600-0684.1994.tb00107.x |
| Popis: | Twenty-one cynomolgus monkeys were immunized with whole inactivated HIV-2 preparations administered with various adjuvants (incomplete Freund's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID50 of a homologous monkey-cell grown, cell-free HIV-2. Seven animals were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibodies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous challenge with a monkey-cell grown cell-free human immunodeficiency virus type 2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text