Mechanistic Similarities of Sesquiterpene Cyclases PenA, Omp6/7, and BcBOT2 Are Unraveled by an Unnatural 'FPP-Ether' Derivative
| Autor: | Viktoria Ravkina, Andreas Kirschning, Vanessa Harms |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Molecular Structure
biology 010405 organic chemistry Stereochemistry Organic Chemistry Ether 010402 general chemistry Sesquiterpene 01 natural sciences Biochemistry Terpenoid 0104 chemical sciences chemistry.chemical_compound chemistry biology.protein Sesquiterpene cyclase Amino Acid Sequence Carbon-Carbon Lyases Physical and Theoretical Chemistry Pentalenene synthase Isomerases Sesquiterpenes Peptide sequence Derivative (chemistry) |
| Zdroj: | Organic Letters. 23:3162-3166 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | The sesquiterpene cyclases pentalenene synthase (PenA) and two Δ6-protoilludene synthases Omp6 and Omp7 convert a FPP ether into several new tetrahydrofurano terpenoids, one of which is also formed as the main product by the sesquiterpene cyclase BcBOT2. Thus, PenA, Omp6/7, and BcBOT2 follow closely related catalytic pathways and induce similar folding of their diphosphate substrates despite low levels of amino acid sequence similarity. Some of the new terpenoids show pronounced olfactoric properties. |
| Databáze: | OpenAIRE |
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