Oxidant stress and essential fatty acids in patients with risk and established ARDS
| Autor: | S.Manimala Rao, I. Krishna Mohan, R Gayani, Madireddy Umamaheswara Rao Naidu, K. Vijay Kumar |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
ARDS Docosahexaenoic Acids Linoleic acid Clinical Biochemistry Biology Lung injury Nitric Oxide Biochemistry Thiobarbituric Acid Reactive Substances Lipid peroxidation Linoleic Acid chemistry.chemical_compound Essential fatty acid Risk Factors Internal medicine Malondialdehyde medicine Humans gamma-Linolenic Acid Nitrites chemistry.chemical_classification Respiratory Distress Syndrome Arachidonic Acid Fatty Acids Essential Biochemistry (medical) Fatty acid alpha-Linolenic Acid General Medicine medicine.disease Eicosapentaenoic acid Oxidative Stress Endocrinology chemistry Eicosapentaenoic Acid Arachidonic acid Lipid Peroxidation Oleic Acid |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 298(1-2) |
| ISSN: | 0009-8981 |
| Popis: | Oxygen free radicals are important mediators of both physiological and pathological events. In acute lung injury, the activated lymphocytes stimulate tumor necrosis factor (TNF) and other cytokines. These lymphokines augment free radical generation by polymorphonuclear leukocytes (PMNLs), macrophages and other cells which may ultimately produce acute respiratory distress syndrome (ARDS). This is supported by our results presented here in that there is a significant increase in lipid peroxidation products in patients with established ARDS. The amount of lipid peroxidation was significantly higher in the established ARDS group compared to patients who are at risk for ARDS. Nitric oxide concentrations were significantly decreased in established ARDS compared to the control and those who are at risk for ARDS. Fatty acid analysis of the plasma phospholipid fraction revealed a significant decreased in linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid levels of n-6 series and alpha-linolenic acid, eicosapentaenoic acid, docosa-hexanenoic acid of n-3 series. Patients who are at risk for ARDS have decreased levels of gamma-linolenic acid of the n-6 series, alpha-linolenic acid and eicosapentaenoic acid of the n-3 series. These results suggest that lipid peroxides and alteration in essential fatty acid metabolism may have a role in the pathogenesis of ARDS. |
| Databáze: | OpenAIRE |
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