Prognostic implications of prostatic urethral involvement in non-muscle-invasive bladder cancer
| Autor: | Trinity J. Bivalacqua, Gregory Joice, Max Kates, Marcus J. Daniels, Nikolai A. Sopko, Andres Matoso, Meera Chappidi, Aaron Brant |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Urology medicine.medical_treatment Urinary system 030232 urology & nephrology Cystectomy Stromal Invasion 03 medical and health sciences 0302 clinical medicine Prostatic urethra Internal medicine Humans Medicine Neoplasm Invasiveness Aged Retrospective Studies Aged 80 and over Urethral Neoplasms Bladder cancer business.industry Proportional hazards model Prostate Middle Aged Prognosis medicine.disease Survival Rate medicine.anatomical_structure Urinary Bladder Neoplasms 030220 oncology & carcinogenesis business Non muscle invasive |
| Zdroj: | World Journal of Urology. 37:2683-2689 |
| ISSN: | 1433-8726 0724-4983 |
| Popis: | Non-muscle-invasive bladder cancer involving the prostatic urethra is associated with pathologic upstaging and shorter survival. We investigated the survival impact of prostatic urethral involvement in non-muscle-invasive patients who are not upstaged at cystectomy. From 2000 to 2016, 177 male patients underwent cystectomy for high-risk non-muscle-invasive bladder cancer and remained pT1, pTis, or pTa, and N0 on final pathology; 63 (35.6%) patients had prostatic urethral involvement and 114 (64.4%) did not. Prostatic involvement was non-invasive (Ta or Tis) in 56 (88.9%) patients and superficially invasive (T1) in 7 (11.1%) patients. No patient had stromal invasion. Log-rank and Cox regression analyses were used to evaluate survival. Compared to patients without prostatic urethral involvement, patients with involvement were more likely to have received intravesical therapy (84.6% vs. 64.4%, p |
| Databáze: | OpenAIRE |
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