Pharmacokinetic Interaction between Magnolol and Piperine in Rats
| Autor: | Jian-Hui Xie, Xiao-Ying Chen, Cailan Li, Xiao-Ping Lai, Xiu-Ting Yu, Yong-Zhuo Liang, Yi-Feng Zheng, Xiu-Fen Wang, Ji Lin, Guanghua Yang, Zi-Ren Su |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Plasma samples
Low dose Pharmaceutical Science 02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy High-performance liquid chromatography Magnolol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Pharmacokinetics Piperine Pharmacology (medical) Magnolol Piperine Pharmacokinetic interaction Co administration 0210 nano-technology Pharmacokinetic interaction Co administration |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 15, No 3 (2016); 631-638 |
| ISSN: | 1596-5996 1596-9827 |
| Popis: | Purpose: To investigate the pharmacokinetic mechanism of interaction between magnolol and piperine when co-administered to rats.Methods: The rats were divided into five groups as follows: magnolol group (625 mg/kg); low dose of piperine group (20 mg/kg); high dose of piperine group (40 mg/kg); low dose of piperine + magnolol group; or high dose of piperine + magnolol group. Plasma samples were collected at regular time intervals after administration of a single dose of magnolol (625 mg/kg, p.o.) alone or piperine (20 or 40 mg/kg, p.o.) in the presence or absence of magnolol (625 mg/kg, p.o.). The concentrations of magnolol and piperine in plasma were measured by a validated high performance liquid chromatography (HPLC) method.Results: Compared with control, the groups given magnolol alone, concomitant administration of piperine and magnolol resulted in significant decrease (p < 0.01) in the AUC and Cmax of magnolol. Interestingly, compared with administration of piperine alone (20 mg/kg), co-administration with magnolol did not significantly (p > 0.05) alter the pharmacokinetic parameters of piperine. However, at high dose (40 mg/kg) of piperine, Cmax of piperine significantly decreased from 4.30 ± 1.47 to 2.50 ± 0.78 μg/mL (p < 0.05).Conclusion: Co-administration of magnolol and piperine decreases plasma concentration of either drug in rats, suggesting that concurrent use of magnolol with piperine or piperine-containing diets would require close monitoring for potential interactions.Keywords: Magnolol, Piperine, Pharmacokinetic interaction, Co administration |
| Databáze: | OpenAIRE |
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