Composition of coronary plaques obtained by directional atherectomy in stable angina: its relation to serum lipids and statin treatment
| Autor: | O. Wiklund, J. Solem, Lars Grip, Malin Levin, Per Albertsson, Thomas Karlsson |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Atherectomy Coronary Male medicine.medical_specialty Atorvastatin medicine.medical_treatment T-Lymphocytes Blood lipids Inflammation Coronary Artery Disease Angina Pectoris Coronary artery disease Atherectomy Double-Blind Method Internal medicine Internal Medicine medicine Image Processing Computer-Assisted Humans Pyrroles Lymphocyte Count Aged Immunity Cellular Apolipoprotein A-I business.industry Vascular disease Middle Aged medicine.disease Combined Modality Therapy Lipids Endocrinology Heptanoic Acids Cardiology Immunohistochemistry lipids (amino acids peptides and proteins) Female Collagen medicine.symptom Hydroxymethylglutaryl-CoA Reductase Inhibitors Inflammation Mediators business Biomarkers medicine.drug Lipoprotein |
| Zdroj: | Journal of internal medicine. 259(3) |
| ISSN: | 0954-6820 |
| Popis: | Objectives. The stability and inflammatory activity in atherosclerotic plaques may be modulated by lipids and lipoproteins as well as the pleiotropic effects of statins. The aim of this study was to analyse the effect of statin treatment as well as the relation of plasma lipids and lipoproteins to tissue composition in atherosclerotic plaques. Design. Patients with stable angina and coronary plaques suitable for directional coronary atherectomy (DCA) were randomized to atorvastatin (80 mg once daily) or placebo (29 randomized, 22 underwent DCA, 11/group). After an average treatment of 10 weeks, patients underwent DCA, tissue specimens were obtained, and the tissue composition was determined by immunohistochemistry. Results. Atorvastatin reduced the T-cell content, but did not change lipid, collagen, smooth muscle cell, or macrophage content. Plasma levels of apolipoprotein AI (apoAI) correlated positively with tissue collagen and inversely with metalloproteinase-9 and macrophage content. About half the specimens contained neutrophil granulocytes. Conclusions. Short-term atorvastatin treatment tended to reduce the T-cell content of atherosclerotic plaques, indicating modulation of cell-mediated immunity. High plasma levels of apoAI correlated with increased collagen content and reduced inflammation, supporting the notion that plasma apoAI stabilizes atherosclerotic plaques. The significance of neutrophils in the lesions merits further study. |
| Databáze: | OpenAIRE |
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