Antimicrobial Resistance Profile and Molecular Characteristics of Staphylococcus aureus Isolates from Hospitalized Adults in Three Regions of Vietnam
| Autor: | Tran Thi Hai Au, Tran Quang Binh, Ha Thi Nguyet Minh, Vu Thi Thu Huong, Do Thi Quynh Nga, Phung Thi Thu Hang, Vu Thi Kim Lien, Nguyen Thai Son |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Methicillin-Resistant Staphylococcus aureus Staphylococcus aureus Genotype medicine.drug_class 030106 microbiology Antibiotics Prevalence Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Multiple Bacterial medicine Humans 030212 general & internal medicine Typing Gene Geography General Medicine Staphylococcal Infections Anti-Bacterial Agents Bacterial Typing Techniques Electrophoresis Gel Pulsed-Field Multiple drug resistance Hospitalization Infectious Diseases Vietnam Multilocus sequence typing Multilocus Sequence Typing |
| Zdroj: | Japanese journal of infectious diseases. 73(3) |
| ISSN: | 1884-2836 |
| Popis: | This study aimed to investigate antimicrobial resistance profile, multidrug resistance (MDR), and molecular characteristics of pathogenic Staphylococcus aureus isolates from hospitalized Vietnamese adults. Two hundred and twenty-three pathogenic S. aureus isolates were obtained from the hospitals located in 3 regions of Vietnam. The minimum inhibitory concentrations were determined to detect the antibiotic susceptibility of the isolates. The molecular characteristics of S. aureus isolates were investigated through antibiotic-resistant genes analysis, staphylococcal cassette chromosome mec typing, pulsed-field gel electrophoresis, and multilocus sequence typing. Substantial differences among the 3 regions were found in the prevalence rates of methicillin-resistant S. aureus (north: 48.6%, central: 58.7%, south: 78.9%) and MDR (north: 65.8%, central: 79.7%, and south: 84.2%). The prevalence rates of the genes tetK/M, aacA/aphD, ermA/B/C, and mecA increased substantially from north to south. ST188-SCCmecIV and ST239-SCCmecII isolates were most commonly found in the 2 largest clusters. ST188 predominance was observed in the largest cluster in methicillin-resistant and methicillin-sensitive S. aureus isolates, including SCCmecIII and SCCmecIVa, in fatal cases. Our results revealed a high occurrence of MDR and possible north-south trend in antibiotic resistance profile, MDR patterns, and frequency of antibiotic-conferring genes among S. aureus isolates. ST188 predominance raises concerns about the global importance of host-adapted ST188 in East Asian populations. |
| Databáze: | OpenAIRE |
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