An Autoimmune Response to Odorant Binding Protein 1a Is Associated with Dry Eye in the Aire-Deficient Mouse
| Autor: | Jason DeVoss, Wen Lu, Lawrence Fong, Norbert P. LeClair, Navdeep K. Grewal, Yafei Hou, Mark S. Anderson, Kellsey Johannes, Ting Yang, Craig Meagher, Erich C. Strauss |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Immunology Keratoconjunctivitis Sicca Mice Nude Mice SCID Thymus Gland Lacrimal gland Biology Receptors Odorant medicine.disease_cause Article Autoimmunity Dacryocystitis Mice Mice Inbred NOD medicine Animals Humans Immunology and Allergy Receptor Transcription factor Autoantibodies Mice Knockout Autoimmune disease Mice Inbred BALB C Dacryoadenitis Autoantibody medicine.disease Disease Models Animal Sjogren's Syndrome medicine.anatomical_structure Dry Eye Syndromes Female Central tolerance Transcription Factors |
| Zdroj: | The Journal of Immunology. 184:4236-4246 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Sjögren’s Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for α-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a, targeted by the autoimmune response. This novel autoantigen is expressed in the thymus in an Aire-dependent manner. The results from our study suggest that defects in central tolerance may contribute to SS and provide a new and clinically relevant model to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surface sequelae. |
| Databáze: | OpenAIRE |
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