Automated determination of neutrophil VCS parameters in diagnosis and treatment efficacy of neonatal sepsis
| Autor: | Zeynep Biyikli, Hatice Tatar Aksoy, Istemi Han Celik, Ece Tuncer, Gamze Demirel, Omer Erdeve, Ugur Dilmen |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Hematologic Tests Neonatal sepsis Neutrophils business.industry Treatment outcome Infant Newborn MEDLINE Gestational age Gestational Age medicine.disease Sensitivity and Specificity Infant Newborn Diseases Treatment efficacy Leukocyte Count Treatment Outcome Sepsis Pediatrics Perinatology and Child Health medicine Humans Female Intensive care medicine business |
| Zdroj: | Pediatric Research. 71:121-125 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | The Coulter LH780 hematology analyzer can evaluate mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS), and distribution width (DW). We sought to investigate the value of volume, conductivity, and scatter (VCS) parameters in diagnosis and treatment efficacy of neonatal sepsis.We observed significant increases in MNV, volume distribution width (VDW), conductivity distribution width (CDW), and significant decreases in MNC and MNS in septic newborns. There were significant decreases in MNV, VDW, and CDW, whereas MNC and MNS increased at the end of the treatment. Gram-negative sepsis caused higher MNV and VDW than Gram-positive sepsis.This is the largest reported study seeking to determine cutoff levels of neutrophil VCS parameters in diagnosis of sepsis, and the first study in the evaluation of treatment efficacy and the effects of sepsis onset time and birth weight. We suggest that neutrophil VCS parameters and their DWs are useful both for early diagnosis and evaluation of treatment efficacy in neonatal sepsis without requirement for any extra blood collection.Peripheral blood samples from 304 newborns, 206 in group I (76 proven and 130 clinical sepsis) and 98 in group II (control group), were studied on diagnosis, 3rd day, and at the end of the treatment. |
| Databáze: | OpenAIRE |
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