Roles of interleukin-11 during acute bacterial pneumonia
| Autor: | Filiz T. Korkmaz, Joseph P. Mizgerd, Matthew R. Jones, Katrina E. Traber, Lee J. Quinton, Ernest L. Dimbo, Elise M. Symer |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bacterial Diseases Myeloid Pulmonology Neutrophils Physiology medicine.medical_treatment Pathology and Laboratory Medicine Epithelium Mice White Blood Cells 0302 clinical medicine Animal Cells Immune Physiology Medicine and Health Sciences Edema Immune Response Mice Knockout Innate Immune System Multidisciplinary Animal Models Pulmonary edema Interleukin-11 3. Good health Interleukin 11 medicine.anatomical_structure Cytokine Infectious Diseases Neutrophil Infiltration Experimental Organism Systems 030220 oncology & carcinogenesis Acute Disease Medicine Cytokines medicine.symptom Cellular Types Anatomy Research Article Science Immune Cells Immunology Inflammation Pulmonary Edema Mouse Models Research and Analysis Methods 03 medical and health sciences Model Organisms Signs and Symptoms Diagnostic Medicine medicine Pneumonia Bacterial Animals Lung Blood Cells business.industry Bacterial pneumonia Biology and Life Sciences Escherichia Coli Infections Epithelial Cells Pneumonia Cell Biology Molecular Development medicine.disease Antibodies Neutralizing respiratory tract diseases 030104 developmental biology Biological Tissue Immune System Animal Studies business Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 8, p e0221029 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Interleukin-11 (IL-11) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection. In this study we addressed the role of IL-11 in acute bacterial pneumonia using a mouse model of E. coli pneumonia. Compared with other related cytokines, IL-11 protein was maintained at high levels in the lung at baseline, with only mild alterations in whole lung and BALF levels during acute infection. The primary source of IL-11 in the lung was the epithelium, but steady state production was not dependent on the inflammatory transcription factor nuclear factor kappa B in cells of either myeloid or epithelial lineage. Blockade of IL-11 with neutralizing antibodies resulted in a mild but significant decrease in neutrophil recruitment and increase in pulmonary edema during pneumonia, without detectable alterations in bacterial clearance. Exogenous IL-11 administration, however, had no effect at baseline or during infection. Overall, we conclude that maintenance of lung IL-11 concentrations may influence acute pulmonary inflammation during infection, albeit modestly. |
| Databáze: | OpenAIRE |
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