The in vitro and in vivo activity of ciprofloxacin
| Autor: | K. Grohe, H. J. Zeiler |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Cefotaxime Nalidixic acid medicine.drug_class Injections Subcutaneous Antibiotics Administration Oral Mice Inbred Strains Microbial Sensitivity Tests Pharmacology Microbiology Mice Nalidixic Acid Ciprofloxacin Ampicillin medicine Animals Humans Norfloxacin Bacteria Dose-Response Relationship Drug Chemistry Bacterial Infections General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Sisomicin Quinolines Cefaclor medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology. 3:339-343 |
| ISSN: | 1435-4373 0722-2211 |
| DOI: | 10.1007/bf01977490 |
| Popis: | The antibacterial activity of ciprofloxacin (Bay o 9867) was compared with those of norfloxacin, nalidixic acid, trimethoprim-sulfamethoxazole, cefaclor, sisomicin and cefotaxime in in vitro and mouse protection studies. Approximately 300 clinical isolates of clinically important gram-positive and gram-negative species were used. The median MICs of ciprofloxacin against gram-positive and gram-negative bacteria ranged from less than or equal to 0.015-1 mg/l. Ciprofloxacin was 2-8 fold more active than norfloxacin and 100-fold more active than nalidixic acid. It also had a wider spectrum of activity against gram-positive organisms including even enterococci. No cross-resistance was observed between ciprofloxacin and beta-lactam antibiotics or aminoglycosides. Only acidic pH conditions decreased its activity. Ciprofloxacin showed rapid bactericidal action against organisms in both the logarithmic and stationary growth phases. In mouse protection studies (intraperitoneal infection) ciprofloxacin was significantly more effective than norfloxacin, ampicillin, trimethoprim-sulfamethoxazole, and also showed excellent activity against Pseudomonas infections. |
| Databáze: | OpenAIRE |
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