Stage migration and pilot studies of reduced chemotherapy supported by positron-emission tomography findings suggest new combined strategies for stage 2 nonseminoma germ cell tumour
| Autor: | Peter J. Ell, M. Joe Ostrowski, R. Tim D. Oliver, Michael V. Williams, J. Ong, David E. Neal, Jonathan Shamash, Yasser Haba, V. Nargund |
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| Rok vydání: | 2008 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Urology medicine.medical_treatment Antineoplastic Agents Pilot Projects Gastroenterology Cohort Studies Retroperitoneal lymph node dissection Testicular Neoplasms Risk Factors Internal medicine medicine Humans Prospective Studies Stage (cooking) Germ cell tumour Neoplasm Staging Chemotherapy medicine.diagnostic_test business.industry Cancer Seminoma Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Survival Analysis Surgery Treatment Outcome Positron emission tomography Positron-Emission Tomography Neoplasm Recurrence Local business Tomography X-Ray Computed |
| Zdroj: | BJU international. 101(5) |
| ISSN: | 1464-410X |
| Popis: | OBJECTIVE To examine the nodal (N+) vs extranodal (M+) staging in each of the International Germ Cell Consensus Classification Group (IGCCCG) subgroups in an audit of 437 patients treated in The Anglian Germ Cell Cancer Group, where chemotherapy was the primary management, as there is an increasingly earlier presentation of patients with less advanced disease who thus face potentially unnecessary treatment. PATIENTS AND METHODS Clinicians from seven centres prospectively registered patients in a central database, and the follow-up was coordinated by one of the authors. RESULTS Between 1982 and 2002, 436 patients (median follow-up 60 months) were registered; 63% of IGCCCG good risk (298), 42% of intermediate (62) and 8% poor risk (77) were stage II; 79% of N+M0 intermediate and poor risk cases (29) were alive, vs only 60% of M+ stage IV cases (92, P |
| Databáze: | OpenAIRE |
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