Genomic variation, origin tracing, and vaccine development of SARS-CoV-2: A systematic review
| Autor: | Geng Tian, Tao Huang, Xiaofei Mo, Jialiang Yang, Xiaoli Shi, Tingting Hui, Jing Sun, Leyi Wang, Qingqing Lu, Tianbao Li, Cheng Guo, Ailan Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty Science (General) media_common.quotation_subject Review Biology Virus Pathogenesis 03 medical and health sciences Q1-390 0302 clinical medicine origin tracing SARS-CoV-2 vaccine Epidemiology medicine 030212 general & internal medicine media_common Infectivity infection mechanism Multidisciplinary SARS-CoV-2 Repertoire COVID-19 medicine.disease Virology Clinical trial 030104 developmental biology Pneumonia (non-human) |
| Zdroj: | The Innovation, Vol 2, Iss 2, Pp 100116-(2021) Innovation (New York, N.y.) |
| ISSN: | 2666-6758 |
| Popis: | COVID-19 has spread globally to over 200 countries with more than 40 million confirmed cases and one million deaths as of November 1, 2020. The SARS-CoV-2 virus, leading to COVID-19, shows extremely high rates of infectivity and replication, and can result in pneumonia, acute respiratory distress, or even mortality. SARS-CoV-2 has been found to be continue rapidly evolving, with several genomic variants emerging in different regions throughout the world. In addition, despite intensive study of the spike protein, its origin and molecular mechanisms in mediating host invasion are still only partially resolved. Finally, the repertoire of drugs for COVID-19 treatment is still limited, with several candidates still under clinical trial and no effective therapeutic yet reported. Although vaccines based on either DNA/mRNA or protein have been deployed, their efficacy against emerging variants requires ongoing study, with multivalent vaccines supplanting the first generation vaccines due to their low efficacy against new strains. Here, we provide a systematic review of studies on the epidemiology, immunological pathogenesis, molecular mechanisms and structural biology, as well as approaches for drug or vaccine development for SARS-CoV-2. Graphical abstract |
| Databáze: | OpenAIRE |
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