Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer)
Autor: | Gaurav Poudyal, Brett A. Clementz, Neeraj Tandon, Anup S. Bidesi, Sara J. M. Arnold, Anil P. Reddy, Elena I. Ivleva, Alan N. Francis, Carolyn B. Sacco, Haekyung Jeon-Slaughter, Matcheri S. Keshavan, John A. Sweeney, Tejas A. Gopal, Carol A. Tamminga, Bradley Witte, Godfrey D. Pearlson |
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Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Oncology
Proband Adult Male medicine.medical_specialty Psychosis Bipolar I disorder Bipolar Disorder Schizoaffective disorder Hippocampal formation Hippocampus Young Adult Internal medicine medicine Image Processing Computer-Assisted Humans Family Bipolar disorder Regular Article Organ Size Middle Aged medicine.disease Mental illness Magnetic Resonance Imaging Psychiatry and Mental health Psychotic Disorders Schizophrenia Case-Control Studies Female Psychology Clinical psychology |
Popis: | This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P = .0007-.02) and SAD (P = .003-.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P = .18-.55). All relative groups had hippocampal volumes not different from controls (P = .12-.97) and higher than those observed in probands (P = .003-.09), except for FreeSurfer measures in bipolar probands vs relatives (P = .64-.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r = .51-.73, P < .05). These findings from a large psychosis sample support decreased hippocampal volume as a putative biomarker for schizophrenia and schizoaffective disorder, but not for psychotic bipolar I disorder, and may reflect a cumulative effect of divergent primary disease processes and/or lifetime medication use. Manual tracing and semiautomated parcellation regional volumetric approaches may provide useful outcomes for defining measurable biomarkers underlying severe mental illness. |
Databáze: | OpenAIRE |
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