B cell growth and differentiation induced by supernatants of transformed epithelial cell lines
| Autor: | Robin E. Callard, Susan H. Smith, John G. Shields, Peter C. L. Beverley, F C Rawle, Matthias Merkenschlager, Iliescu |
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| Rok vydání: | 1986 |
| Předmět: |
Cell division
Cellular differentiation T cell Immunology Biology medicine Humans Immunology and Allergy Growth Substances Interleukin 4 B cell B-Lymphocytes Lymphokines Cell growth Lymphokine Cell Differentiation Epithelial Cells Cell biology Antigens Differentiation B-Lymphocyte medicine.anatomical_structure Urinary Bladder Neoplasms Cell culture Antigens Surface Interleukin-4 Cell Division |
| Zdroj: | European Journal of Immunology. 16:1017-1019 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830160825 |
| Popis: | Growth and differentiation of B cells is thought to be regulated by soluble factors derived from T cells. However, human T cell lines and hybridomas have proved to be notoriously unreliable and unstable sources of such factors. We report here that three stable human bladder carcinoma cell lines T24, RT4 and 5637 produce, in a constitutive fashion, factors which promote growth and differentiation of human B cells. |
| Databáze: | OpenAIRE |
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