Potential anti-cancer and anti-Candida activity of Zn-derived foams
Autor: | Liliana Grenho, Marta M. Alves, Nuno P. Mira, L M Marques, Nuno A. Pedro, Maria de Fátima Montemor, Sara B. Salazar, Maria Helena Fernandes, S. Eugénio |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
biology Scanning electron microscope Biomedical Engineering chemistry.chemical_element 02 engineering and technology General Chemistry General Medicine Electrolyte Zinc 021001 nanoscience & nanotechnology biology.organism_classification In vitro 03 medical and health sciences symbols.namesake 030104 developmental biology chemistry symbols General Materials Science 0210 nano-technology Candida albicans Raman spectroscopy Nuclear chemistry |
Zdroj: | Journal of materials chemistry. B. 6(18) |
ISSN: | 2050-7518 |
Popis: | Zinc (Zn)-derived foams have been prepared from an alkaline electrolyte solution by galvanostatic electrodeposition under different conditions. A detailed physico-chemical characterization was performed by Raman spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). A pioneer application of these foams in medical implant-related applications was investigated. The in vitro behaviour of these Zn-derived foams in simulated physiological conditions was studied. The results revealed that the presence of zinc oxide was important enough to change the in vitro behaviour of these materials. The potential of these Zn-derived foams in inhibiting bone cancer cell proliferation - osteoscarcoma cells - and important pathogenic fungi responsible for implant-related infections -Candida albicans- was examined. Furthermore, the foams were evaluated for cytocompatibility with normal human osteoblasts. The results obtained allowed us to conclude that Zn-derived foams have an interesting potential for anti-cancer and anti-Candida activity, targeted for bone-related implant applications, suggesting that this novel material may have potential for further clinical studies. |
Databáze: | OpenAIRE |
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