HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
| Autor: | Ana Félix, Silvia de Sanjosé, F. Xavier Bosch, Sara Tous, Laia Alemany |
|---|---|
| Přispěvatelé: | Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
genotype retrospective study Uterine Cervical Neoplasms Human papillomavirus type 18 0302 clinical medicine Cervix cancer Human papillomavirus type 58 Genotype Human papillomavirus type 16 Prevalence Human papillomavirus type 59 Human papillomavirus type 53 Human papillomavirus type 56 Human papillomavirus type 11 Invasive cervical carcinoma Papillomaviridae Human papillomavirus type 52 Human papillomavirus type 51 Aged 80 and over Cervical cancer Human papillomavirus type 70 adult Middle Aged cohort analysis Vaccination Retrospective study aged Infectious Diseases female priority journal Human papillomavirus type 69 030220 oncology & carcinogenesis Human papillomavirus type 68 Female Human papillomavirus type 67 Human papillomavirus type 66 Cohort study Adult medicine.medical_specialty HPV Càncer de coll uterí Papillomaviruses Hpv detection Article lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences Human papillomavirus type 39 Wart virus SDG 3 - Good Health and Well-being Virology Internal medicine Human papillomavirus type 35 medicine Humans lcsh:RC109-216 controlled study Human papillomavirus type 31 human Human papillomavirus type 33 Papil·lomavirus Genotyping Human papillomavirus type 30 Aged Retrospective Studies Human papillomavirus type 73 virus detection Gynecology nonhuman Portugal Human papillomavirus type 91 business.industry HPV Positive Retrospective cohort study medicine.disease major clinical study 030104 developmental biology DNA Viral Human papillomavirus type 42 Human papillomavirus type 45 business uterine cervix cancer |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Papillomavirus Research Papillomavirus Research, Vol 2, Iss, Pp 41-45 (2016) Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | Objectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (p Highlights • Wide snapshot of HPV genotype profile of invasive carcinomas of the cervix in a European country. • Characterization of HPV by LiPA25 assay of 882 cases of invasive carcinomas of the cervix diagnosed before 1949. • Maintenance of HPV types associated with invasive carcinomas of the cervix along the XX century. |
| Databáze: | OpenAIRE |
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