Healthcare Resource Utilization Among Patients in England with Systemic Sclerosis-Associated Interstitial Lung Disease: A Retrospective Database Analysis

Autor: Alicia Gayle, Margarida Alves, Christina Raabe, Francesco Del Galdo, Toby M. Maher, Nils Schoof, Prithwiraj Das, Deborah Clarke
Přispěvatelé: National Institute for Health Research, British Lung Foundation
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Healthcare utilization
Databases
Factual
Population
Interstitial lung disease
Disease
behavioral disciplines and activities
Interquartile range
Internal medicine
Observational study
Medicine
Electronic health records
Humans
Pharmacology (medical)
CPRD
education
skin and connective tissue diseases
General Clinical Medicine
Original Research
Aged
Retrospective Studies
Aged
80 and over
education.field_of_study
Scleroderma
Systemic
integumentary system
business.industry
Medical record
Retrospective cohort study
General Medicine
Middle Aged
Patient Acceptance of Health Care
respiratory system
medicine.disease
SSc-ILD
respiratory tract diseases
England
Systemic sclerosis
Health Resources
Female
1115 Pharmacology and Pharmaceutical Sciences
Health Expenditures
business
Lung Diseases
Interstitial
Rare disease
Zdroj: Advances in Therapy
ISSN: 0741-238X
Popis: Introduction Systemic sclerosis-associated interstitial lung disease (SSc-ILD) places a substantial burden on patients and healthcare systems. The objectives of this study were to describe clinical characteristics and assess healthcare resource utilization and costs of patients with SSc-ILD in England, compared with patients with non-pulmonary organ involvement related to SSc (SSc-OOI). Methods This population-based retrospective study used data from the Clinical Practice Research Datalink linked to Hospital Episode Statistics. Data were extracted from medical records dated January 1, 2005 to March 31, 2016. Patients with SSc were identified and placed in subgroups based on organ involvement: SSc-ILD, SSc-OOI, and both (SSc-ILD-OOI). Patients with SSc-ILD-OOI were included in both the SSc-ILD and SSc-OOI subgroups. All-cause healthcare costs, excluding medication costs, were calculated to 2016 British pounds sterling (£). Results This study included 675 patients with SSc: 174 (26%) had neither ILD nor other organ involvement (OOI); 127 (19%) had SSc-ILD; 477 (71%) had SSc-OOI; 103 (15%) had SSc-ILD-OOI. Age-weighted median [interquartile range (IQR)] annual healthcare costs per patient were: £1496 (£664–£2817) in SSc only; £6375 (£3451–£15,041) in SSc-ILD; £4084 (£1454–£10,105) in SSc-OOI; £6632 (£4023–£17,009) in SSc-ILD-OOI. In multivariate analysis, older age at diagnosis, diagnosis of anemia, and number of comorbid diseases were associated with higher yearly healthcare costs. Conclusion The annual healthcare cost for patients with SSc-ILD is substantial, and higher than that of patients with SSc-OOI or SSc only. These results quantify the economic burden of SSc-ILD in a real-world setting, and highlight the need for treatment of this disease. Electronic supplementary material The online version of this article (10.1007/s12325-020-01330-0) contains supplementary material, which is available to authorized users.
Plain Language Summary SSc is a rare disease that causes fibrosis, or thickening, of the skin. In some patients, SSc can also affect the lungs (‘SSc-ILD’) or other organs, e.g., the heart (‘SSc-OOI’). Patients with SSc-ILD typically have high healthcare costs; however, it is not clear how costs for SSc-ILD compare with those for SSc-OOI. To investigate this, we evaluated the costs associated with SSc-ILD and compared them with those for SSc only or SSc-OOI. In this England-based study, the annual healthcare costs for patients with SSc-ILD were approximately 50% higher than for those without lung disease (SSc only) or SSc-OOI. These results highlight the importance of promptly diagnosing and treating patients with lung fibrosis complicating SSc. Electronic supplementary material The online version of this article (10.1007/s12325-020-01330-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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