Standard-Dose Intradermal Influenza Vaccine Elicits Cellular Immune Responses Similar to Those of Intramuscular Vaccine in Men With and Those Without HIV Infection
| Autor: | Weiping Cao, James Stevens, Shivaprakash Gangappa, Shikha Garg, Sonja J Olsen, Justine S. Liepkalns, Timothy H. Holtz, Margarita Mishina, Marcel E. Curlin, Fatimah S. Dawood, Samuel Amoah, Prabda Praphasiri, Suryaprakash Sambhara, Paul J. Carney, Jin Hyang Kim, Jessie C. Chang, Lauren Beacham, Zhu Guo, Stefan Fernandez |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male 0301 basic medicine Immunoglobulin A Influenza vaccine Population HIV Infections Hemagglutinin Glycoproteins Influenza Virus CD8-Positive T-Lymphocytes Antibodies Viral Immunoglobulin G Interferon-gamma 03 medical and health sciences Influenza A Virus H1N1 Subtype 0302 clinical medicine Immune system Influenza Human Humans Immunology and Allergy Medicine Avidity 030212 general & internal medicine education B-Lymphocytes Immunity Cellular education.field_of_study biology Tumor Necrosis Factor-alpha business.industry Vaccination Hemagglutination Inhibition Tests Middle Aged Thailand CD4 Lymphocyte Count 030104 developmental biology Infectious Diseases Immunization Influenza Vaccines Antibody Formation Immunology biology.protein Interleukin-2 business |
| Zdroj: | The Journal of Infectious Diseases. 220:743-751 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiz205 |
| Popis: | Background Human immunodeficiency virus (HIV)–infected persons are at a higher risk of severe influenza. Although we have shown that a standard-dose intradermal influenza vaccine versus a standard-dose intramuscular influenza vaccine does not result in differences in hemagglutination-inhibition titers in this population, a comprehensive examination of cell-mediated immune responses remains lacking. Methods Serological, antigen-specific B-cell, and interleukin 2–, interferon γ–, and tumor necrosis factor α–secreting T-cell responses were assessed in 79 HIV-infected men and 79 HIV-uninfected men. Results The route of vaccination did not affect the immunoglobulin A and immunoglobulin G (IgG) plasmablast or memory B-cell response, although these were severely impaired in the group with a CD4+ T-cell count of Conclusions The route of vaccination had no effect on antibody responses, antibody avidity, T-cell responses, or B-cell responses in HIV-infected or HIV-uninfected subjects. With the serological and cellular immune responses to influenza vaccination being impaired in HIV-infected individuals with a CD4+ T-cell count of Clinical trials registration NCT01538940. |
| Databáze: | OpenAIRE |
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