Long-term adjuvant tamoxifen in early breast cancer: effect on bone mineral density in postmenopausal women
| Autor: | Tommy Fornander, L. Blomqvist, A Mattsson, L E Rutqvist, H.E. Sjoberg, U Glas |
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| Rok vydání: | 1990 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Randomization Osteoporosis Urology Breast Neoplasms General Biochemistry Genetics and Molecular Biology Breast cancer Bone Density Internal medicine medicine Humans Aged Randomized Controlled Trials as Topic Bone mineral business.industry Obstetrics and Gynecology Middle Aged medicine.disease Menopause Tamoxifen Endocrinology medicine.anatomical_structure Cortical bone Female business medicine.drug Hormone |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 8(6) |
| ISSN: | 0732-183X |
| Popis: | The decrease in sex steroid hormone levels after the onset of menopause is associated with bone loss and subsequent osteoporosis. Tamoxifen has antiestrogenic properties and may thus theoretically decrease bone mineral density, particularly after long-term treatment. Bone mineral density (BMD) was assessed in 75 recurrence-free postmenopausal breast cancer patients included in a randomized trial of adjuvant tamoxifen (40 mg daily) for 2 or 5 years versus no adjuvant endocrine therapy. The measurements were done about 7 years after the initial randomization. BMD was measured with single-photon absorptiometry (SPA) at two levels of the distal forearm representing cortical and trabecular bone. The BMD was found to be similar among tamoxifen patients compared with the controls. For cortical bone, the BMD was 1.03 g/cm2 (95% confidence interval [Cl], 0.97 to 1.09) among tamoxifen patients and 1.03 g/cm2 (95% Cl, 0.96 to 1.11) in controls. For trabecular bone, the values were 0.74 g/cm2 (95% Cl, 0.70 to 0.79) and 0.73 g/cm2 (95% Cl, 0.68 to 0.79), respectively. The results thus did not indicate an accelerated postmenopausal bone loss with long-term adjuvant tamoxifen. |
| Databáze: | OpenAIRE |
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