Parieto-occipital sulcus widening differentiates posterior cortical atrophy from typical Alzheimer disease
| Autor: | Tiziana Carandini, Elio Scarpini, Matteo Mercurio, Annalisa Colombi, Andrea Arighi, Paola Basilico, Elisa Scola, Luca Sacchi, Marta Scarioni, Fabio Triulzi, Daniela Galimberti, Giorgio G. Fumagalli, Giorgio Conte, Anna M. Pietroboni |
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| Přispěvatelé: | Neurology, Amsterdam Neuroscience - Neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Visual rating scale
genetic structures FDG fluorodeoxyglucose CON Controls Precuneus Audiology PCA Posterior cortical atrophy lcsh:RC346-429 PA Posterior scale PET Positron emission tomography LBD Lewy Body Dementia 0302 clinical medicine Gray Matter Cerebral Cortex VOSP Visual object and space perception test AUC Area under the ROC Curve 05 social sciences Regular Article MTA Medial temporal scale Sulcus Magnetic Resonance Imaging MMSE Mini Mental State Examination medicine.anatomical_structure Neurology lcsh:R858-859.7 Occipital Lobe Parieto-occipital sulcus Alzheimer Disease Differential Diagnosis Posterior Cortical Atrophy Voxel based morphometry medicine.medical_specialty MNI Montreal Neurological Institute Cognitive Neuroscience Grey matter lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 03 medical and health sciences Atrophy medicine OF Orbito-Frontal scale Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging AT Anterior temporal scale PCS Posterior cingulate sulcus scale WM white matter lcsh:Neurology. Diseases of the nervous system FEW Family wise error PRE Precuneus scale AD Alzheimer disease business.industry POS Parieto-occipital sulcus scale Posterior cortical atrophy GM grey matter Voxel-based morphometry medicine.disease Posterior cingulate VBM Voxel Based Morphometry Neurology (clinical) business MRI magnetic resonance imaging CSF Cerebrospinal Fluid 030217 neurology & neurosurgery |
| Zdroj: | Fumagalli, G G, Basilico, P, Arighi, A, Mercurio, M, Scarioni, M, Carandini, T, Colombi, A, Pietroboni, A M, Sacchi, L, Conte, G, Scola, E, Triulzi, F, Scarpini, E & Galimberti, D 2020, ' Parieto-occipital sulcus widening differentiates posterior cortical atrophy from typical Alzheimer disease ', NeuroImage: Clinical, vol. 28, 102453 . https://doi.org/10.1016/j.nicl.2020.102453 NeuroImage : Clinical NeuroImage: Clinical, Vol 28, Iss, Pp 102453-(2020) NeuroImage: Clinical, 28:102453. Elsevier BV |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102453 |
| Popis: | Highlights • Parieto-occipital sulcus visual rating scale can distinguish PCA from typical AD. • Visual rating scales have been validated using VBM and Brainvisa Morphologist. • Visual rating score reflects sulcal widening rather than grey matter reduction. Objectives Posterior Cortical Atrophy (PCA) is an atypical presentation of Alzheimer disease (AD) characterized by atrophy of posterior brain regions. This pattern of atrophy is usually evaluated with Koedam visual rating scale, a score developed to enable visual assessment of parietal atrophy on magnetic resonance imaging (MRI). However, Koedam scale is complex to assess and its utility in the differential diagnosis between PCA and typical AD has not been demonstrated yet. The aim of this study is therefore to spot a simple and reliable MRI element able to differentiate between PCA and typical AD using visual rating scales. Methods 15 patients who presented with progressive complex visual disorders and predominant occipitoparietal hypometabolism on PET-FDG were selected from our centre and compared with 30 typical AD patients and 15 healthy subjects. We used previously validated visual rating scales including Koedam scale, which we divided into three major components: posterior cingulate, precuneus and parieto-occipital. Subsequently we validated the results using the automated software Brainvisa Morphologist and Voxel Based Morphometry (VBM). Results Patients with PCA, compared to typical AD, showed higher widening of the parieto-occipital sulcus, assessed both with visual rating scales and Brainvisa. In the corresponding areas, the VBM analysis showed an inverse correlation between the results obtained from the visual evaluation scales with the volume of the grey matter and a direct correlation between the same results with the cerebrospinal fluid volume. Conclusions A visually based rating scale for parieto-occipital sulcus can distinguish Posterior Cortical Atrophy from typical Alzheimer disease. |
| Databáze: | OpenAIRE |
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