Stimulation of Intestinal Sodium and Water Transport in Vivo by Angiotensin II and Analogs*
| Autor: | Robert M. Carey, Michael J. Peach, Nigel R. Levens, Judith A. Poat, Kenneth A. Munday |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Colon Stereochemistry Phenylalanine Intestinal absorption Structure-Activity Relationship Endocrinology Internal medicine medicine Animals Cycloheximide Alanine chemistry.chemical_classification Water transport Dose-Response Relationship Drug Angiotensin II Sodium Water Rats Amino acid Jejunum Intestinal Absorption Biochemistry chemistry Glycine Leucine |
| Zdroj: | Endocrinology. 107:1946-1953 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-107-6-1946 |
| Popis: | Studies in pressor and myotropic preparations employing analogs of angiotensin II (A II) demonstrate that the carboxy-terminal amino acid residue, phenylalanine, is essential for the hormonal response. The present study demonstrates that important differences exist between the structural requirements for stimulation of intestinal fluid absorption and those for pressor and myotropic systems. Phenylalanine can be replaced with the aliphatic amino acids, leucine, alanine, or glycine, and by aamino-butyric acid with retention of full agonist activity, but with some variation in the relative potencies of these compounds in stimulating rat intestinal fluid transfer. Certain similarities exist for structural modification of other important residues, as [D-Pya6]A II and [Phe4, Ala8]A II were essentially inactive on all three biological systems. The analogs studied exhibited the following order of potency in stimulating intestinal transport: [Abu8]A II, [Sar1 Leu8]A II > [Sar1, Gly8]A II > [Asp1, lle5]A II > [Asn1... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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