| Autor: |
Tony Wyss-Coray, PATRICK MCALPINE, Timothy Wu, William Goodyer, Maxim Markovic, Emily Trimm, Shixuan Liu, Sevahn Vorperian, Gaetano D'Amato, Stefan Veizades, Francisco Galdos, Antoine De Morrée, Charles Chang, Alex Colville, Sean Wu, William Harper, Albert Wu, Jonathan Maltzman, David A. Relman, Stephen Chang, SoRi Jang, Bronwyn Scott |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Vorperian, S K, Moufarrej, M N, Tabula Sapiens Consortium & Quake, S R 2022, ' Cell types of origin of the cell-free transcriptome ', Nature Biotechnology, vol. 40, no. 6, pp. 855-861 . https://doi.org/10.1038/s41587-021-01188-9 |
| DOI: |
10.1038/s41587-021-01188-9 |
| Popis: |
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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