Chronotherapeutic Drug Delivery Systems - An Approach to Circadian Rhythms Diseases
| Autor: | K. V. Ramana Murthy, S. A. Sunil, MU Uhumwangho, K Latha, N Sreenivasa Rao, M V Srikanth |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Drug
Peptic Ulcer medicine.medical_specialty media_common.quotation_subject Drug availability Pharmaceutical Science Disease Pharmacology Dosage form Drug Delivery Systems Neoplasms Humans Medicine Circadian rhythm Intensive care medicine media_common Inflammation business.industry Drug Chronotherapy Controlled release Asthma Circadian Rhythm Cardiovascular Diseases Drug delivery business |
| Zdroj: | Current Drug Delivery. 8:622-633 |
| ISSN: | 1567-2018 |
| Popis: | The purpose of writing this review on chronotherapeutic drug delivery systems (ChrDDs) is to review the literatures with special focus on ChrDDs and the various dosage forms, techniques that are used to target the circadian rhythms (CR) of various diseases. Many functions of the human body vary considerably in a day. ChrDDs refers to a treatment method in which in vivo drug availability is timed to match circadian rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. Several techniques have been developed but not many dosage forms for all the diseases are available in the market. ChrDDs are gaining importance in the field of pharmaceutical technology as these systems reduce dosing frequency, toxicity and deliver the drug that matches the CR of that particular disease when the symptoms are maximum to worse. Finally, the ultimate benefit goes to the patient due the compliance and convenience of the dosage form. Some diseases that follow circadian rhythms include cardiovascular diseases, asthma, arthritis, ulcers, diabetes etc. ChrDDs in the market were also discussed and the current technologies used to formulate were also stated. These technologies include Contin® , Chronotopic®, Pulsincaps®, Ceform®, Timerx®, Oros®, Codas®, Diffucaps®, Egalet®, Tablet in capsule device, Core-in-cup tablet technology. A coated drug-core tablet matrix, A bi-layered tablet, Multiparticulate-based chronotherapeutic drug delivery systems, Chronoset and Controlled release microchips. |
| Databáze: | OpenAIRE |
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