Histamine exerts both direct H2-mediated and indirect catecholaminergic effects on heart rate in pythons
| Autor: | Nini Skovgaard, Tobias Wang, Sanne Enok, Maja Fuhlendorff Jensen, William Joyce, Simon Nørgaard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
030110 physiology
0106 biological sciences 0301 basic medicine Physiology Snake Autonomic regulation NANC Adrenergic Stimulation Reptile Pharmacology 010603 evolutionary biology 01 natural sciences Biochemistry 03 medical and health sciences chemistry.chemical_compound Endocrinology Histamine H2 receptor Humoral regulation medicine Ecology Evolution Behavior and Systematics Catecholaminergic Histaminergic chemistry Catecholamine Blood pressure Cholinergic Animal Science and Zoology Histamine medicine.drug |
| Zdroj: | Nørgaard, S, Joyce, W, Jensen, M F, Enok, S, Skovgaard, N & Wang, T 2021, ' Histamine exerts both direct H 2-mediated and indirect catecholaminergic effects on heart rate in pythons ', Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, vol. 191, no. 2, pp. 347-355 . https://doi.org/10.1007/s00360-020-01338-6 |
| DOI: | 10.1007/s00360-020-01338-6 |
| Popis: | The vertebrate heart is regulated by excitatory adrenergic and inhibitory cholinergic innervations, as well as non-adrenergic non-cholinergic (NANC) factors that may be circulating in the blood or released from the autonomic nerves. As an example of NANC signaling, an increased histaminergic tone, acting through stimulation of H2 receptors, contributes markedly to the rise in heart rate during digestion in pythons. In addition to the direct effects of histamine, it is also known that histamine can reinforce the cholinergic and adrenergic signaling. Thus, to further our understanding of the histaminergic regulation of the cardiovascular response in pythons, we designed a series of in vivo experiments complemented by in vitro experiments on sinoatrial and vascular ring preparations. We demonstrate the tachycardic mechanism of histamine works partly through a direct binding of cardiac H2 receptors and in part through a myocardial histamine-induced catecholamine release, which strengthens the sympathetic adrenergic signaling pathway. |
| Databáze: | OpenAIRE |
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