Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism
| Autor: | Stefania Bonadonna, Ettore C. degli Uberti, M. Gola, Mauro Doga, Andrea Giustina, Maria Rosaria Ambrosio, Maria Chiara Zatelli, Marta Bondanelli, Alessandro Onofri |
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| Přispěvatelé: | Bondanelli, M, Bonadonna, S, Ambrosio, Mr, Doga, M, Gola, M, Onofri, A, Zatelli, Mc, Giustina, Andrea, DEGLI UBERTI, Ec |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Diastole Blood Pressure Doppler echocardiography Biology Left ventricular hypertrophy Gigantism Electrocardiography Ventricular Dysfunction Left Insulin-like growth factor Endocrinology Internal medicine Glucose Intolerance Acromegaly medicine Humans Insulin-Like Growth Factor I medicine.diagnostic_test Human Growth Hormone medicine.disease Echocardiography Doppler Glucose Circulatory system Hypertrophy Left Ventricular Endocrine gland |
| Zdroj: | Metabolism. 54:1174-1180 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2005.03.025 |
| Popis: | Chronic growth hormone (GH)/insulin-like growth factor I (IGF-I) excess is associated with considerable mortality in acromegaly, but no data are available in pituitary gigantism. The aim of the study was to evaluate the long-term effects of early exposure to GH and IGF-I excess on cardiovascular and metabolic parameters in adult patients with pituitary gigantism. Six adult male patients with newly diagnosed gigantism due to GH secreting pituitary adenoma were studied and compared with 6 age- and sex-matched patients with acromegaly and 10 healthy subjects. Morphologic and functional cardiac parameters were evaluated by Doppler echocardiography. Glucose metabolism was assessed by evaluating glucose tolerance and homeostasis model assessment index. Disease duration was significantly longer (P < .05) in patients with gigantism than in patients with acromegaly, whereas GH and IGF-I concentrations were comparable. Left ventricular mass was increased both in patients with gigantism and in patients with acromegaly, as compared with controls. Left ventricular hypertrophy was detected in 2 of 6 of both patients with gigantism and patients with acromegaly, and isolated intraventricular septum thickening in 1 patient with gigantism. Inadequate diastolic filling (ratio between early and late transmitral flow velocity |
| Databáze: | OpenAIRE |
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