A Prospective Study of Diffusion-weighted Magnetic Resonance Imaging as an Early Prognostic Biomarker in Chemoradiotherapy in Squamous Cell Carcinomas of the Anus
| Autor: | L. Durrant, Maria A. Hawkins, Daniel P. Bulte, R. Cooke, C. Jacobs, S.M. Ng, C Qi, Rebecca Muirhead, K.Y. Chu, Victoria Y Strauss, Pradeep S. Virdee, Vicky Goh |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Effective diffusion coefficient Anal cancer Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged medicine.diagnostic_test business.industry Anal Squamous Cell Carcinoma Magnetic resonance imaging Chemoradiotherapy Middle Aged Anus Neoplasms Prognosis medicine.disease Anus Tumor Burden Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Biomarker (medicine) Female Radiology Neoplasm Recurrence Local business |
| Zdroj: | Clinical Oncology. 32:874-883 |
| ISSN: | 0936-6555 |
| DOI: | 10.1016/j.clon.2020.09.003 |
| Popis: | Aims The use of diffusion-weighted magnetic resonance imaging (DW-MRI) as a prognostic marker of treatment response would enable early individualisation of treatment. We aimed to quantify the changes in mean apparent diffusion coefficient (ΔADC_mean) between a DW-MRI at diagnosis and on fraction 8–10 of chemoradiotherapy (CRT) as a biomarker for cellularity, and correlate these with anal squamous cell carcinoma recurrence. Materials and methods This prospective study recruited patients with localised anal cancer between October 2014 and November 2017. DW-MRI was carried out at diagnosis and after fraction 8–10 of radical CRT. A region of interest was delineated for all primary tumours and any lymph nodes >2 cm on high-resolution T 2-weighted images and propagated to the ADC map. Routine clinical follow-up was collected from Nation Health Service electronic systems. Results Twenty-three of 29 recruited patients underwent paired DW-MRI scans. Twenty-six regions of interest were delineated among the 23 evaluable patients. The median (range) tumour volume was 13.6 cm^3 (2.8–84.9 cm^3). Ten of 23 patients had lesions with ΔADC_mean ≤ 20%. With a median follow-up of 41.2 months, four patients either failed to have a complete response to CRT or subsequently relapsed. Three of four patients with disease relapse had lesions demonstrating ΔADC_mean Conclusions We demonstrated a potential correlation between patients with ΔADC_mean |
| Databáze: | OpenAIRE |
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