ALBA Screening Instrument (ASI): A brief screening tool for Lewy Body Dementia

Autor: Angel Golimstok, Waleska Berrios, Juan Ignacio Rojas, Nuria Campora, Marcela Fernandez, M. Fernández, Erica Bogliotti, M. M. Garcia Basalo, Edgardo Cristiano, M.J. Garcia Basalo, M. Ojea Quintana
Rok vydání: 2017
Předmět:
Lewy Body Disease
Male
Aging
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
Health (social science)
SCREENING TEST
ASI
Medicina Clínica
Neuropsychological Tests
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Neuroimaging
Internal medicine
parasitic diseases
mental disorders
medicine
Humans
Dementia
Screening tool
030212 general & internal medicine
Psychiatry
Screening instrument
Aged
Aged
80 and over
COGNITIVE ASSESSMENT
Lewy body
DEMENTIA
Curve analysis
Neuropsychology
Case-control study
Middle Aged
medicine.disease
LEWY BODY DEMENTIA
Early Diagnosis
Case-Control Studies
Female
Medicina Critica y de Emergencia
Geriatrics and Gerontology
Psychology
Gerontology
geographic locations
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Zdroj: Archives of Gerontology and Geriatrics. 70:67-75
ISSN: 0167-4943
DOI: 10.1016/j.archger.2017.01.001
Popis: Background Early detection of neurodegenerative diseases is essential for treatment and proper care of these patients. Screening tools available today are effective for several types of dementia. However, there is no one specific for Lewy Body Dementia (LBD). Objectives The aim of this paper is to present a tool for early detection of LBD, accessible even for non-medical staff. Methods We stratified subjects (MMSE > 20) into four groups: health controls (HC), Mild Cognitive Impairment (MCI), LBD and other dementias (Alzheimer and vascular). All subjects (age range 50–90) were examined with a comprehensive neuropsychological and neuropsychiatric evaluation, as well as neuroimaging to differentiate diagnosis between groups, fulfilling corresponding criteria. Both neurologists and neuropsychologists were blind to the performance on clinical evaluations and ASI, respectively. The sensitivity and specificity of the instrument were determined to differentiate LBD from other groups. Results We evaluated 427 subjects, 91 HC, 140 with MCI and 196 with dementia. In the dementia group, 75 were diagnosed with LBD and 121 with other dementias. ASI total score was 12.7 ± 0.4 for LBD, 2.9 ± 0.2 for HC, 5 ± 0.7 for MCI, and 5.4 ± 2.6 for other causes of dementia. ROC curve analysis showed a sensitivity of 90.7% and a specificity of 93.6% stands, with 9 as the cutoff with better test performance compared against other groups. Conclusion ASI is a brief screening tool for LBD with high sensitivity and specificity and useful even for non-medical staff. Fil: Garcia Basalo, M. M.. Hospital Italiano; Argentina Fil: Fernandez, M. C.. Hospital Italiano; Argentina. Asociacion Lewy Body Argentina; Argentina Fil: Ojea Quintana, M.. Hospital Italiano; Argentina. Asociacion Lewy Body Argentina; Argentina Fil: Rojas, J. I.. Hospital Italiano; Argentina Fil: Garcia Basalo, M. J.. Hospital Italiano; Argentina. Asociacion Lewy Body Argentina; Argentina Fil: Bogliotti, E.. Hospital Italiano; Argentina Fil: Cámpora, Nuria Elide. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina Fil: Fernandez, M.. Hospital Italiano; Argentina Fil: Berrios, W.. Hospital Italiano; Argentina Fil: Cristiano, E.. Hospital Italiano; Argentina Fil: Golimstok, Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina. Asociacion Lewy Body Argentina; Argentina
Databáze: OpenAIRE
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