Reducing the clinical burden of ranibizumab treatment for neovascular age-related macular degeneration using an individually planned regimen
| Autor: | Sophie-Alexia Niderprim, Christina Gianniou, Irmela Mantel, A. Deli, Aude Ambresin |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Visual acuity Visual Acuity Angiogenesis Inhibitors Antibodies Monoclonal Humanized Drug Administration Schedule Cellular and Molecular Neuroscience Recurrence Ranibizumab Age related medicine Humans Prospective Studies Trial registration Prospective cohort study Aged Aged 80 and over Planned Treatment Regimen business.industry Middle Aged Clinical Science Macular degeneration medicine.disease Sensory Systems Surgery Ophthalmology Regimen Treatment Outcome Intravitreal Injections Retreatment Wet Macular Degeneration Female Drug Monitoring medicine.symptom business Algorithms Tomography Optical Coherence medicine.drug |
| Zdroj: | The British Journal of Ophthalmology British Journal of Ophthalmology, vol. 98, no. 9, pp. 1192-1196 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2013-304556 |
| Popis: | AIMS: The purpose of this study was to clinically validate an individually planned treatment regimen for neovascular age-related macular degeneration (nAMD), termed, observe and plan. This regimen was based on the predictability of an individual's need for retreatment and aimed to reduce the clinical burden, while obtaining good functional results. METHODS: This was a prospective case series that included 104 patients (115 eyes) with treatment-naive nAMD. Following three loading doses of ranibizumab, monthly observation visits allowed the disease recurrence interval to be determined. The recurrence interval was reduced by 2 weeks to give the retreatment interval for the next three injections. Periodical control visits (at least every 6 months) allowed the effectiveness of the treatment to be assessed and individual intervals adjusted. RESULTS: Mean visual acuity (VA) improved by 8.7 and 9.8 letters in months 3 and 12, respectively. The mean number of injections during the 12-month study was 7.8, while the mean number of ophthalmic examinations between months 3 and 12 was 3.97. The mean treatment interval after the loading doses was 1.97 months. CONCLUSIONS: The observe-and-plan regimen significantly improved VA. This was obtained with fewer clinic visits compared with other regimens, which could ease the burden of nAMD treatment. TRIAL REGISTRATION NUMBER: Commission cantonale (VD) d'éthique de la recherché Clinique, Université de Lausanne, Protocole 351/11. |
| Databáze: | OpenAIRE |
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