Influence of Lamotrigine Addition on Computerized Background EEG Parameters in Severe Epileptogenic Encephalopathies
| Autor: | D. Volanschi, G. Foletti |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Alpha (ethology) Electroencephalography Lamotrigine Audiology Central nervous system disease Humans Medicine Evoked Potentials Computerized eeg Cerebral Cortex Epilepsy medicine.diagnostic_test Triazines business.industry Signal Processing Computer-Assisted Dominant frequency Middle Aged medicine.disease Anticonvulsant Neurology Anesthesia Anticonvulsants Drug Therapy Combination Female Neurology (clinical) business Lennox–Gastaut syndrome medicine.drug |
| Zdroj: | European Neurology. 34:87-89 |
| ISSN: | 1421-9913 0014-3022 |
| DOI: | 10.1159/000119518 |
| Popis: | In 12 adults with typical Lennox-Gastaut syndrome and partial epilepsies with secondary bilateral synchrony unsatisfactorily controlled by current antiepileptic drugs, the following computerized background EEG parameters were studied before and during beneficial antiepileptic effect of lamotrigine addition: absolute and relative spectral power density; alpha/theta index; dominant frequency of occipital alpha, theta and delta bands. The only significant influence of lamotrigine addition was a moderate decrease of the median and mean absolute delta power (p0.01). We concluded there was a poor influence of therapeutic doses of lamotrigine on the background diffuse slow dysrhythmias characteristic to severe early encephalopathies which engender both severe secondary epilepsies and different degrees of mental handicap. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|