Eradication of Helicobacter pylori for the Prevention of Peptic Ulcer Rebleeding
| Autor: | Nuria Cañete, Javier P. Gisbert, Xavier Calvet, R. Garcia-Gravalos, Pedro Almela, Nuria Fernández, J M Piqué, Manuel Castro-Fernandez, Angel Cosme, Santos Santolaria, Miguel Montoro, Faust Feu, Fernando Borda, Felipe Bory, Adolfo Benages, Ángeles Pérez-Aisa, R. Azntulárez |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Peptic Ulcer medicine.medical_specialty Time Factors medicine.drug_class Proton-pump inhibitor Rapid urease test Peptic Ulcer Hemorrhage macromolecular substances Gastroenterology Helicobacter Infections Ranitidine Clarithromycin Internal medicine Prevalence medicine Humans Pharmacology (medical) Prospective Studies Aged Breath test Hepatology Ulcer bleeding Helicobacter pylori biology medicine.diagnostic_test business.industry Incidence (epidemiology) Amoxicillin General Medicine Middle Aged biology.organism_classification medicine.disease digestive system diseases Hospitalization Treatment Outcome Infectious Diseases Peptic ulcer Female Peptic ulcer bleeding Upper gastrointestinal bleeding business Follow-Up Studies medicine.drug |
| Zdroj: | Helicobacter. 12:279-286 |
| ISSN: | 1523-5378 1083-4389 |
| DOI: | 10.1111/j.1523-5378.2007.00490.x |
| Popis: | Aim: To evaluate the effect of Helicobacter pylori eradication on ulcer bleeding recurrence in a prospective, long-term study including more than 400 patients. Methods: Patients with peptic ulcer bleeding were prospectively included. H. pylori infection was confirmed by rapid urease test, histology or 13C-urea breath test. Several eradication regimens were used. Ranitidine 150 mg was administered daily until eradication was confirmed by breath test 8 weeks after completing eradication therapy. Patients with therapy failure received a second or third course of therapy. Patients with eradication success did not receive maintenance anti-ulcer therapy, and were controlled yearly with a repeated breath test. Results: Four hundred and twenty-two patients were followed up for at least 12 months, with a total of 906 patient-years of follow up. Mean age was 59 years, and 35% were previous nonsteroidal anti-inflammatory drug (NSAID) users. Sixty-nine percent had duodenal, 24% gastric, and 7% pyloric ulcer. Recurrence of bleeding was demonstrated in two patients at 1 year (incidence: 0.22% per patient-year of follow up), which occurred after NSAID use in both cases. Conclusion: Peptic ulcer rebleeding does not occur in patients with complicated ulcers after H. pylori eradication. Maintenance anti-ulcer (antisecretory) therapy is not necessary if eradication is achieved. |
| Databáze: | OpenAIRE |
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