RUNX2 alleles associated with BMD in Scottish women; interaction of RUNX2 alleles with menopausal status and body mass index
| Autor: | Stuart H. Ralston, David M. Reid, Nigel Alexander Morrison, Tanya Vaughan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Histology Genotype Physiology Endocrinology Diabetes and Metabolism Molecular Sequence Data Population Osteoporosis Core Binding Factor Alpha 1 Subunit Body Mass Index Cohort Studies Gene Frequency Bone Density Internal medicine medicine Humans Allele education Allele frequency Femoral neck Bone mineral Analysis of Variance education.field_of_study Base Sequence business.industry musculoskeletal neural and ocular physiology Middle Aged musculoskeletal system medicine.disease DNA-Binding Proteins Endocrinology medicine.anatomical_structure Scotland Transcription Factor AP-2 Cohort Female Menopause business Body mass index Transcription Factors |
| Zdroj: | Bone. 34:1029-1036 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2004.02.004 |
| Popis: | Bone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish cohort to decipher the role of RUNX2 alleles in regulating BMD. The alleles of RUNX2 within the glutamine–alanine repeat were determined by Msp A1I restriction digest. Allele frequencies estimated from Scottish cohort were G allele, 0.87 ± 0.01; A allele, 0.08 ± 0.01; and 11Ala alanine deletion allele, 0.05 ± 0.01. Analysis of covariance (ANCOVA) was used to adjust for the covariates weight and age for BMD at the femoral neck (FN). The A allele was associated with higher FN BMD ( P = 0.035) within a postmenopausal subgroup of the population ( n = 312). The effect of RUNX2 A alleles increased with increasing weight; A alleles were associated with FN BMD in those above the median BMI (BMI > 25), while no association was observed in thin/normal (BMI ≤ 25) postmenopausal women. Glutamine variants and an alanine insertion were identified within the group. These data suggest that the RUNX2 alleles are associated with BMD in a menopause- and weight-dependent manner. |
| Databáze: | OpenAIRE |
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