Moringa oleifera-rich diet and T cell calcium signaling in spontaneously hypertensive rats
| Autor: | Eugène Attakpa, B. Seri, N. A. Khan, Nicodème W. Chabi, G. A. Bertin, J.-M. Atègbo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology T cell T-Lymphocytes 030204 cardiovascular system & hematology Rats Inbred WKY Moringa 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Internal medicine Rats Inbred SHR medicine Animals Secretion Platelet Calcium Signaling Antihypertensive Agents Calcium signaling chemistry.chemical_classification Moringa oleifera Plant Extracts Body Weight General Medicine Rats Plant Leaves 030104 developmental biology Endocrinology Blood pressure medicine.anatomical_structure chemistry Hypertension Polyunsaturated fatty acid |
| Zdroj: | Physiological research. 66(5) |
| ISSN: | 1802-9973 |
| Popis: | Moringa oleifera is a plant whose fruits, roots and leaves have been advocated for traditional medicinal uses. The physico-chemical analysis shows that Moringa oleifera contains more dietary polyunsaturated fatty acids (PUFA) than saturated fatty acids (SFA). The consumption of an experimental diet enriched with Moringa oleifera extracts lowered blood pressure in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) rats as compared to rats fed an unsupplemented control diet. Anti-CD3-stimulated T cell proliferation was diminished in both strains of rats fed the Moringa oleifera. The experimental diet lowered secretion of interleukin-2 in SHR, but not in WKY rats compared with rats fed the control diet. Studies of platelets from patients with primary hypertension and from SHR support the notion that the concentration of intracellular free calcium [Ca2+]i is modified in both clinical and experimental hypertension. We observed that the basal, [Ca2+]i was lower in T cells of SHR than in those of WKY rats fed the control diet. Feeding the diet with Moringa oleifera extracts to WKY rats did not alter basal [Ca2+]i in T cells but increased basal [Ca2+]i in SHR. Our study clearly demonstrated that Moringa oleifera exerts antihypertensive effects by inhibiting the secretion of IL-2 and modulates T cell calcium signaling in hypertensive rats. |
| Databáze: | OpenAIRE |
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